The short answer
Our database lists 7,156 US startup investors focused on healthcare & digital health, and 2,215 of those with a known state are based outside California, New York and Massachusetts. The most represented states are California (2,709), New York (1,305), Massachusetts (624), Texas (279), Illinois (235). (Zalarma investor database, as of 2026-11-01.)
What healthcare & digital health investors look for
- Lead with the regulatory path. Healthcare investors want to see that you know whether you are a device, software as a medical device, a service, or a lab test, and what clearance (if any) you need before revenue.
- Name your buyer precisely: health system, payer, employer, provider group or patient. The sale cycle you describe tells an investor how much runway you really need.
- Clinical advisors and pilot sites count as traction at pre-seed. A signed pilot letter from a regional hospital often matters more than a famous name on the cap table.
- Physician angel groups and health-system venture arms are natural first checks outside the big hubs; they understand the workflow and can open doors to pilots.
Where they are
US states with the most healthcare & digital health investors in our database.
| State | Investors |
|---|---|
| California | 2,709 |
| New York | 1,305 |
| Massachusetts | 624 |
| Texas | 279 |
| Illinois | 235 |
| Florida | 203 |
| Washington | 172 |
| Pennsylvania | 122 |
| North Carolina | 102 |
| Colorado | 102 |
| Ohio | 82 |
| Washington, DC | 77 |
Top metros
Healthcare & digital health investors by state
What stages they back
Of the 7,099 records in this group that list a stage, here is how many invest at each one (investors often list several).
Investors by stage
Who they are
The mix of investor types tells you where your first checks are most likely to come from.
Investors by type
Sectors they focus on
Sector focus as listed on each record. Generalists who list many sectors are counted in each.
Investors by sector focus
Typical check sizes
Based on the 6,638 records that list a check size (we use the low end of a stated range).
Investors by typical check size
Active firms outside California, New York and Massachusetts
Firms ranked by how many of their investors in this group appear in our database, counting only investors based outside the three biggest hubs. A starting map, not a ranking of quality.
| Firm | Main stages | Listed |
|---|---|---|
| VentureSouth | Seed, Series A | 25 |
| Thompson Street Capital Partners | Series B+ | 19 |
| Plexus Capital, LLC | Seed, Series A, Series B+ | 15 |
| Moving Capital | Seed, Series A, Series B+ | 12 |
| Monroe Capital LLC | Seed, Series A, Series B+ | 10 |
| S3 Ventures | Seed, Series A, Series B+ | 10 |
| Golden Seeds | Seed, Series A | 10 |
| Wolfpack Investor Network | Pre-seed, Seed | under 10 |
| Alliance of Angels | Seed, Series A | under 10 |
| Baird Capital | Seed, Series A, Series B+ | under 10 |
About this data
Counts are records in the Zalarma investor database, as of 2026-11-01: angels, venture firms and their partners, micro-VCs, family offices, corporate VCs and accelerators that list startup investing. One investor can appear in several stage or sector rows. Stage, sector and check size come from what each record lists, so not every record has every field. Counts under 10 are not shown. Firm names are listed; we do not publish personal contact details on this site. Read how we build and check the data.
Frequently asked questions
How many healthcare & digital health investors are there in the US?
The Zalarma investor database lists 7,156 US startup investors in this group as of 2026-11-01. It is a count of records in our database, not of the whole market.
Are most of them in Silicon Valley?
No. 2,215 of those with a known state are based outside California, New York and Massachusetts.
How should I approach them?
Shortlist the investors whose stage, sector and check size match your round, find a warm path for the top 25, and send a short, specific note to the rest. Our guides cover both.
Can Zalarma introduce me?
Tell us about your round and within 2 business days we will send 5 hand-picked investors, each with a one-line why-they-fit. We never share your details with investors without your OK.